An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos

Early human embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here the authors present LiCAT-seq, a method enabling simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells and map chromatin accessibility and transcriptome landscapes for human pre-implantation embryos

SlideSpace: Heuristic design of a hybrid presentation medium

The Slide and Canvas metaphors are two ways of helping people create visual aids for oral presentations. Although such physical metaphors help both authors and audiences make sense of material, they also constrain authoring in ways that can negatively impact presentation delivery. In this article, we derive heuristics for the design of presentation media that are independent of any underlying physical metaphors. We use these heuristics to craft a new kind of presentation medium called SlideSpace-one that combines hierarchical outlines, content collections, and design rules to automate the real-time, outline-driven synthesis of hybrid Slide-Canvas visuals. Through a qualitative study of SlideSpace use, we validate our heuristics and demonstrate that such a hybrid presentation medium can combine the advantages of existing systems while mitigating their drawbacks. Overall, we show how a heuristic design approach helped us challenge entrenched physical metaphors to create a fundamentally digital presentation medium with the potential to transform the activities of authoring, delivering, and viewing presentations

Magnetic Carbon Quantum Dots/Iron Oxide Composite Based on Waste Rice Noodle and Iron Oxide Scale: Preparation and Photocatalytic Capability

To provide an economical magnetic photocatalyst and introduce an innovative approach for efficiently utilizing discarded waste rice noodle (WRN) and iron oxide scale (IOS), we initially converted WRN into carbon quantum dots (CQDs) using a hydrothermal method, simultaneously calcining IOS to obtain iron oxide (FeOx). Subsequently, we successfully synthesized a cost-effective, magnetic CQDs/FeOx photocatalytic composite for the first time by combining the resulting CQDs and FeOx. Our findings demonstrated that calcining IOS in an air atmosphere enhanced the content of photocatalytically active α-Fe2O3, while incorporating WRN-based CQDs into FeOx improved the electron-hole pair separation, resulting in increased O2 reduction and H2O oxidation. Under optimized conditions (IOS calcination temperature: 300 °C; carbon loading: 11 wt%), the CQDs/FeOx composite, utilizing WRN and IOS as its foundation, exhibited exceptional and reusable capabilities in photodegrading methylene blue and tetracycline. Remarkably, for methylene blue, it achieved an impressive degradation rate of 99.30% within 480 min, accompanied by a high degradation rate constant of 5.26 × 10−3 min−1. This composite demonstrated reusability potential for up to ten photocatalytic cycles without a significant reduction in the degradation efficiency, surpassing the performance of IOS and FeOx without CQDs. Notably, the composite exhibited strong magnetism with a saturation magnetization strength of 34.7 emu/g, which enables efficient and convenient recovery in photocatalytic applications. This characteristic is highly advantageous for the large-scale industrial utilization of photocatalytic water purification